Cy7-N-羟基琥珀酰亚胺酯|Cyanine7 NHS ester|金畔生物

Cy7-N-羟基琥珀酰亚胺酯

货号:AGF1349A-5mg
包装:1mg,5mg,25mg,50mg

  • 英文名:Cyanine7 NHS ester
  • 分子式:C41H48ClN3O4
  • 分子量:682.29
  • 品牌:lumiprobe
  • 外观:green powder
  • 产品详情质检信息

    订购货号 产品名称及规格
    15020 Cyanine7 NHS ester, 1 mg
    25020 Cyanine7 NHS ester, 5 mg
    45020 Cyanine7 NHS ester, 25 mg
    55020 Cyanine7 NHS ester, 50 mg
    65020 Cyanine7 NHS ester, 100 mg

     

    胺类活性染料,近红外荧光染料,Cy7®的改进的类似物。
    近红外荧光素可以被用来利用生物组织的近红外窗口。在这个光谱区域,高度增强的组织透明度使得活体成像成为可能。该染料可用于制备CY7标记的生物分子来进行后续试验,如活体研究及药物开发相关实验。
    Cy7的特殊结构加固了中心聚亚甲基(polymethyne)链的稳定性。这种增强的分子结构会使其量子产率较其母结构提供20%,因此它的荧光强度会更大。
    该试剂在标记时需要共溶剂有机溶剂。水溶Cy7 NHS ester可以用于蛋白NIR标记。
    Cy7-N-羟基琥珀酰亚胺酯|Cyanine7 NHS ester|金畔生物
     
    推荐手册
    氨基分子的NHS酯标记(请联系金畔生物获取)
    Cy® is a trademark of GE Healthcare.

    Spectral properties

    Appearance: green powder
    Molecular weight: 682.29
    Molecular formula:

    C41H48ClN3O4

    Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
    Quality control: NMR 1H (95%) and 13C, TLC, functional testing
    Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
    MSDS: Download

     

    Excitation maximum, nm: 750
    Extinction coefficient at excitation maximum, Lmol-1cm -1: 199000
    Emission maximum, nm: 773
    Fluorescence quantum yield: 0.3

    Product citations

    1. Zhang, R.; Yang, J.; Radford, D.C.; Fang, Y.; Kope?ek, J. FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate.Macromolecular Bioscience, in press. doi: 10.1002/mabi.201600125
    2. Pérez-Medina, C.; Abdel-Atti, D.; Tang, J.; Zhao, Y.; Fayad, Z.A.; Lewis, J.S.; Mulder, W.J.M.; Reiner, T. Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy. Nature Communications2016, 7, 11838. doi: 10.1038/ncomms11838
    3. Zhao, Y.; Fay, F.; Hak, S.; Manuel Perez-Aguilar, J.; Sanchez-Gaytan, B.L.; Goode, B.; Duivenvoorden, R.; de Lange Davies, C.; Bjørkøy, A.; Weinstein, H.; Fayad, Z.A.; Pérez-Medina, C.; Mulder, W.J.M. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nature Communications2016, 7, 11221. doi: 10.1038/ncomms11221
    4. Dhande, Y.K.; Wagh, B.S.; Hall, B.C.; Sprouse, D.; Hackett, P.B.; Reineke, T.M. N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery. Biomacromolecules2016, 17(3), 830–840. doi:10.1021/acs.biomac.5b01555
    5. Kim, J.B.; Park, K.; Ryu, Ji.; Lee, J.J.; Lee, M.W.; Cho, H.S.; Nam, H.S.; Park, O.K.; Song, J.W.; Kim, T.S.; Oh, D.J.; Gweon, D.; Oh, W.-Y.; Yoo, H.; Kim, J.W. Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors. Scientific Reports2016, 6, 22608. doi: 10.1038/srep22608
    6. Tolstyka, Z.P.; Phillips, H.; Cortez, M.; Wu, Y.; Ingle, N.; Bell, J.B.; Hackett, P.B.; Reineke, T.M. Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery. ACS Biomaterials Science & Engineering2016, 2(1), 43–55. doi: 10.1021/acsbiomaterials.5b00312
    7. Turcheniuk, K.; Dumych, T.; Bilyy, R.; Turcheniuk, V.; Bouckaert, J.; Vovk, V.; Chopyak, V.; Zaitsev, V.; Mariot, P.; Prevarskaya, N.; Boukherrouba, R.; Szunerits, S. Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites. RSC Advances2016, 6(2), 1600–1610. doi: 10.1039/c5ra24662h
    8. Rudnick-Glick, S.; Corem-Salkmon, E.; Grinberg, I.; Yehuda, R.; Margel, S. Near IR fluorescent conjugated poly(ethylene glycol)bisphosphonate nanoparticles for in vivo bone targeting in a young mouse model. Journal of Nanobiotechnology2015, 13(1), 80. doi: 10.1186/s12951-015-0126-0
    9. Alexander, S.C.; Busby, K.N.; Cole, C.M.; Zhou, C.Y.; Devaraj, N.K. Site-Specific Covalent Labeling of RNA by Enzymatic Transglycosylation. Journal of the American Chemical Society2015, 137(40), 12756–12759. doi: 10.1021/jacs.5b07286
    10. Yu, Q.; Wei, Z.; Shi, J.; Guan, S.; Du, N.; Shen, T.; Tang, H.; Jia, B.; Wang, F.; Gan, Z. Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules2015, 16(9), 2645–2655. doi: 10.1021/acs.biomac.5b00460